| Dr Sasha Radjenovic |
|
Research
The subject of my research is Quantitative
MRI: a set of methods for the acquisition and analysis of Magnetic
Resonance images, which enable non-invasive and objective tissue
characterisation. The conventional MRI has already revolutionised the practice of
clinical radiology. Quantitative MRI is currently exerting a similar
impact in the field of biomedical research. The translation between basic and clinical science is greatly
enhanced and accelerated by the use of quantitative MRI, which acts
as a catalyst in this process. The alterations in tissue structure and function occur as a
result of a series of molecular and cellular events, but ahead of
the onset of clinical symptoms, as illustrated by this generalised
model of pathogenesis cascade. Quantitative MRI allows objective and non-invasive measurement of
tissue characteristics at the stage within the pathogenesis cascade
where the potential for successful treatment is far grater than in
the established disease, where the degree of irreversible damage is
often significant. 
Furthermore, biomarkers which reflect this tissue stage of
pathogenesis, are particularly attractive, because it can be argued
that intervention becomes necessary only when cellular and molecular
self-repair homeostasis feedback mechanisms start to break down.
My research into quantitative MRI included the development of
methods for pharmacokinetic modelling of dynamic contrast enhanced
MRI, morphometry, and relaxation times measurement and mapping.
I have applied these methods in studies of disease aetiology, lesion
diagnosis and grading, and in monitoring response to therapy.
Clinical studies involved rheumatoid arthritis, breast cancer and
ischemic heart disease.
Quantitative MRI?
A set of methods for the acquisition and analysis of magnetic resonance images, which enable non-invasive and objective tissue characterisation.